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Self-Assessment Modules

Test Name
5 Human Prion Diseases

At the end of this module, the participant will be able to:

  1. Describe the role of cellular prion protein in the pathogenesis of prion disease.
  2. Define type 1 and type 2 prion protein
  3. Contrast clinical and histopathologic features of types MM1 and VV2 sporadic Jakob-Creutzfeldt disease.
  4. Define the sensitivity of immunohistochemical staining and immunoblot analysis in the diagnosis of sporadic prion disease.
  5. Describe the histopathology of Gerstmann-Straussler-Scheinker disease and fatal familial insomnia.
  6. Contrast clinical and pathologic features of variant and sporadic prion diseases.
  7. Define clinical and laboratory features of variably protease sensitive prionopathy.
  8. Choose optimal decontamination methods for contaminated instruments, surfaces, and tissues.
(attempts allowed: 3)
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